The Universal Selection Source: Plastics & Elastomers

Industry News

BPA Alternative BPS Exposure May Increase Breast Cancer Aggressiveness

Published on 2017-04-17. Author : SpecialChem

Hard Plastics
Hard Plastics
ORLANDO -- A new study finds that Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, shows the potential for increasing the aggressiveness of breast cancer through its behavior as an endocrine-disrupting chemical. The results, which tested BPS in human breast cancer cells, were presented ENDO 2017, the Endocrine Society’s 99th annual meeting in Orlando, Fla.

BPS Exhibits Similar Behavior as BPA


BPS is found in polycarbonate hard plastics, currency bills and thermal paper receipts as well as many products touted to be free of BPA, a known endocrine-disrupting chemical suspected of having multiple possible health risks.

"Despite hopes for a safer alternative to BPA, studies have shown BPS to exhibit similar estrogen-mimicking behavior to BPA,” said the study’s principal investigator, Sumi Dinda, Ph.D., associate professor at Oakland University School of Health Sciences, Rochester, Mich.

Their study confirmed that BPS acts like estrogen in breast cancer cells, Dinda said, adding, “So far, BPS seems to be a potent endocrine disruptor.”

Effect of BPA on BRCA1 Gene


He and his colleagues studied the effects of BPS on estrogen receptor-alpha and the BRCA1 gene. Most breast cancers are estrogen receptor positive, and, according to the National Cancer Institute, 55 to 65 percent of women who inherit a harmful mutation in the BRCA1 gene will develop breast cancer.

Using two commercially available breast cancer cell lines obtained from women with estrogen-receptor-positive breast cancer, the research team exposed the cancer cells to varying strengths of BPS or to an inactive substance as a control.
  • The investigators also treated the breast cancer cells with estradiol (estrogen) and found that BPS acted like estrogen in multiplying breast cancer cells, Dinda said.
  • Compared with the control, BPS heightened the protein expression in estrogen receptor and BRCA1 after 24 hours, as did estrogen. 
  • After a six-day treatment with BPS, the breast cancer cells in both cell lines reportedly increased in number by 12 percent at the lowest dose (4 micromolars) and by 60 percent at 8 micromolars.

The research team then blocked the BPS-induced proliferation of breast cancer cells by treating the cells with anti-estrogen drugs, which are used to block estrogen’s action onto estrogen binding proteins (estrogen receptors) in breast cancer cells.

Dinda said their findings suggest that BPS may cause breast cancer to become more aggressive. Although further study of BPS in breast cancer cells is needed for confirmation, he suggested that “if a woman has a mutated BRAC1 gene and uses products containing BPS, her risk for developing breast cancer may increase further.”

Co-author Katie Aleck, a research assistant at Oakland University, will present the study results at the meeting.

About Endocrine Society


Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is one of the world’s oldest and largest organizations of scientists devoted to hormone research and physicians who care for people with hormone-related conditions. The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries.

PS: If you liked this News, you might enjoy our Plastics & Elastomers Industry Newsletter. All the Industry News delivered twice a week right to your inbox. Sign up here!


Source: Endocrine Society
Be the first to comment on "BPA Alternative BPS Exposure May Increase Breast Cancer Aggressiveness"

Leave a comment





Your email address and name will not be published submitting a comment or rating implies your acceptance to SpecialChem Terms & Conditions

Tutorial

High Temperature Plastics: How to Well Control Melt Temperature

Well measure & adjust the melt temperature of your high temperature plastics (PA, PPA, PPS...)

Sitecore.Data.Items.Item

Channel Alerts

Receive weekly digests on hot topics

Receive your alerts

Back to Top