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Genetically Modified Biomolecules

SpecialChem / Jun 1, 2007

Pathway engineering is a multidisciplinary field that enables microbial cells to be exploited for human use. The concept involves utilizing technologies to manipulate a microorganism to use any carbon source to produce a range of desired biomolecules. The substrate glucose, for example, can be converted to a wide range of products such as enzymes, proteins, peptides, vitamins, amino acids and organic acids as well as the biofuels ethanol and hydrogen. The range of possibilities is making this discipline the new standard for establishing efficient production of bioproducts. Pathway engineering involves directed modification of cellular physiology through the introduction, deletion, and/or modification of metabolic pathways of a cell based on an understanding of the cellular physiology under the conditions to be used in the commercial manufacturing process. The approach typically calls for collaborative input from a variety of disciplines, including biochemistry, molecular biology, chemical engineering, and computational sciences.

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